Publication Date:
2004-05-15
Description:
Although the ability of engrafted stem cells to regenerate tissue has received much attention, the molecular mechanisms controlling regeneration are poorly understood. In the Drosophila male germline, local activation of the Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway maintains stem cells; germline stem cells lacking Jak-STAT signaling differentiate into spermatogonia without self-renewal. By conditionally manipulating Jak-STAT signaling, we find that spermatogonia that have initiated differentiation and are undergoing limited mitotic (transit-amplifying) divisions can repopulate the niche and revert to stem cell identity. Thus, in the appropriate microenvironment, transit-amplifying cells dedifferentiate, becoming functional stem cells during tissue regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brawley, Crista -- Matunis, Erika -- R01HD40307/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 May 28;304(5675):1331-4. Epub 2004 May 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, 725 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143218" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Cell Division
;
DNA-Binding Proteins/metabolism
;
Drosophila/*physiology
;
*Drosophila Proteins
;
Germ Cells/cytology/*physiology
;
Male
;
Mitosis
;
Protein-Tyrosine Kinases/metabolism
;
*Regeneration
;
STAT Transcription Factors
;
Signal Transduction
;
Spermatocytes/physiology
;
Spermatogonia/*cytology/*physiology
;
Stem Cells/cytology/*physiology
;
Testis/cytology
;
Trans-Activators/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
