Publication Date:
2004-02-21
Description:
Despite much progress in understanding how extrinsic signaling regulates stem cell self-renewal, little is known about how cell-autonomous gene regulation controls this process. In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically to produce daughter GSCs and cystoblasts, the latter of which develop into germline cysts. Here, we show that removing the translational repressor Nanos from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to differentiate into germline cysts. Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Zhong -- Lin, Haifan -- HD33760/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 26;303(5666):2016-9. Epub 2004 Feb 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Duke University Medical School, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14976263" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Cell Differentiation
;
Cell Division
;
Drosophila/*cytology/embryology/genetics/growth & development
;
Drosophila Proteins/genetics/*physiology
;
Female
;
Genes, Insect
;
Germ Cells/*cytology/physiology
;
Hot Temperature
;
Larva/cytology/growth & development
;
Male
;
Mutation
;
Oocytes/cytology/physiology
;
Oogenesis
;
Ovary/cytology/embryology/growth & development
;
Phenotype
;
RNA-Binding Proteins/genetics/*physiology
;
Stem Cells/*cytology/physiology
;
Transgenes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
