Publication Date:
2004-02-07
Description:
Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no effect on the persistent mnemonic-related activity, which is instead modulated by D1 receptors. This associates the D2 receptor with a specific component of working memory circuitry and fractionates the modulatory effects of D1 and D2 receptors on the neural machinery of a cognitive process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Min -- Vijayraghavan, Susheel -- Goldman-Rakic, Patricia S -- P50 MH068789/MH/NIMH NIH HHS/ -- P50 MH44866/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 6;303(5659):853-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA. min.wang@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14764884" target="_blank"〉PubMed〈/a〉
Keywords:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
;
Animals
;
Benzazepines/pharmacology
;
Cues
;
Dopamine Agonists/pharmacology
;
Dopamine Antagonists/pharmacology
;
Dopamine D2 Receptor Antagonists
;
Dose-Response Relationship, Drug
;
Electrophysiology
;
Macaca mulatta
;
Male
;
Memory/*physiology
;
Neurons/*physiology
;
Prefrontal Cortex/*physiology
;
Psychomotor Performance
;
Quinpirole/pharmacology
;
Raclopride/pharmacology
;
Receptors, Dopamine D1/agonists/antagonists & inhibitors/metabolism
;
Receptors, Dopamine D2/agonists/*metabolism
;
Reward
;
Saccades
;
Salicylamides/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
