Publication Date:
2003-08-09
Description:
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santarelli, Luca -- Saxe, Michael -- Gross, Cornelius -- Surget, Alexandre -- Battaglia, Fortunato -- Dulawa, Stephanie -- Weisstaub, Noelia -- Lee, James -- Duman, Ronald -- Arancio, Ottavio -- Belzung, Catherine -- Hen, Rene -- New York, N.Y. -- Science. 2003 Aug 8;301(5634):805-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12907793" target="_blank"〉PubMed〈/a〉
Keywords:
8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
;
Animals
;
Antidepressive Agents/*pharmacology
;
Antidepressive Agents, Second-Generation/pharmacology
;
Antidepressive Agents, Tricyclic/pharmacology
;
Behavior, Animal/*drug effects
;
Cell Division/drug effects/radiation effects
;
Conditioning (Psychology)
;
Dentate Gyrus/cytology/drug effects/physiology
;
Fear
;
Feeding Behavior/drug effects
;
Fluoxetine/*pharmacology
;
Grooming/drug effects
;
Hippocampus/cytology/drug effects/*physiology/radiation effects
;
Long-Term Potentiation/radiation effects
;
Male
;
Mice
;
Mice, Knockout
;
Neurons/drug effects/*physiology
;
Receptors, Serotonin/genetics/metabolism
;
Receptors, Serotonin, 5-HT1
;
Stress, Physiological/drug therapy/physiopathology
;
Synaptic Transmission/radiation effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
