Publication Date:
2003-08-02
Description:
Reelin is an extracellular protein that is crucial for layer formation in the embryonic brain. Here, we demonstrate that Reelin functions postnatally to regulate the development of the neuromuscular junction. Reelin is required for motor end-plate maturation and proper nerve-muscle connectivity, and it directly promotes synapse elimination. Unlike layer formation, neuromuscular junction development requires a function of Reelin that is not mediated by Disabled1 or very-low-density lipoprotein receptors and apolipoprotein E receptor 2 receptors but by a distinct mechanism involving its protease activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quattrocchi, Carlo C -- Huang, Cheng -- Niu, Sanyong -- Sheldon, Michael -- Benhayon, David -- Cartwright, Joiner Jr -- Mosier, Dennis R -- Keller, Flavio -- D'Arcangelo, Gabriella -- New York, N.Y. -- Science. 2003 Aug 1;301(5633):649-53.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Cain Foundation Laboratories, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12893944" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Axons/metabolism
;
Cell Adhesion Molecules, Neuronal/genetics/metabolism/pharmacology/*physiology
;
Culture Media, Conditioned
;
Diaphragm/innervation
;
Extracellular Matrix Proteins/genetics/metabolism/pharmacology/*physiology
;
LDL-Receptor Related Proteins
;
Mice
;
Mice, Neurologic Mutants
;
Microscopy, Confocal
;
Microscopy, Electron
;
Motor Endplate/ultrastructure
;
Motor Neurons/metabolism
;
Muscle, Skeletal/innervation
;
Mutation
;
Nerve Tissue Proteins/genetics/metabolism
;
Neuromuscular Junction/*growth &
;
development/metabolism/*physiology/ultrastructure
;
Receptors, LDL/genetics/metabolism
;
Receptors, Lipoprotein/genetics/metabolism
;
Schwann Cells/metabolism
;
Serine Endopeptidases
;
Serine Proteinase Inhibitors/pharmacology
;
Sulfones/pharmacology
;
Synapses/*physiology/ultrastructure
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
