Publication Date:
2003-03-01
Description:
Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Longo, Valter D -- Finch, Caleb E -- AG 01028/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1342-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA. vlongo@usc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610293" target="_blank"〉PubMed〈/a〉
Keywords:
*Aging
;
Animals
;
Biological Evolution
;
Caenorhabditis elegans/genetics/physiology
;
Caloric Restriction
;
Drosophila/genetics/physiology
;
Dwarfism/physiopathology
;
Gene Expression Regulation
;
Glucose/*metabolism
;
Growth Hormone/metabolism
;
Human Growth Hormone/metabolism
;
Humans
;
Insulin-Like Growth Factor I/*metabolism
;
*Longevity/genetics
;
Mice
;
Models, Animal
;
Mutation
;
Signal Transduction
;
Yeasts/genetics/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
