Publication Date:
2002-11-09
Description:
Schwann cells in developing and regenerating peripheral nerves express elevated levels of the neurotrophin receptor p75NTR. Neurotrophins are key mediators of peripheral nervous system myelination. Our results show that myelin formation is inhibited in the absence of functional p75NTR and enhanced by blocking TrkC activity. Moreover, the enhancement of myelin formation by endogenous brain-derived neurotrophic factor is mediated by the p75NTR receptor, whereas TrkC receptors are responsible for neurotrophin-3 inhibition. Thus p75NTR and TrkC receptors have opposite effects on myelination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cosgaya, Jose M -- Chan, Jonah R -- Shooter, Eric M -- NS04270/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1245-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Building, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424382" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies/immunology
;
Axons/physiology
;
Brain-Derived Neurotrophic Factor/pharmacology/physiology
;
Coculture Techniques
;
Ganglia, Spinal/cytology
;
Immunohistochemistry
;
Mice
;
Models, Neurological
;
Myelin P0 Protein/metabolism
;
Myelin Sheath/*physiology
;
Myelin-Associated Glycoprotein/metabolism
;
Neurotrophin 3/pharmacology/physiology
;
Rats
;
Rats, Sprague-Dawley
;
Receptor, Nerve Growth Factor
;
Receptor, trkB/metabolism
;
Receptor, trkC/metabolism
;
Receptors, Nerve Growth Factor/immunology/*physiology
;
Reverse Transcriptase Polymerase Chain Reaction
;
Schwann Cells/*physiology
;
Sciatic Nerve/cytology/metabolism
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
