Publication Date:
2002-06-18
Description:
The transmembrane protein LAT (linker for activation of T cells) couples the T cell receptor (TCR) to downstream signaling effectors. Mice homozygous for a mutation of a single LAT tyrosine residue showed impeded T cell development. However, later they accumulated polyclonal helper T (TH) cells that chronically produced type 2 cytokines in large amounts. This exaggerated TH2 differentiation caused tissue eosinophilia and massive maturation of plasma cells secreting to immunoglobulins of the E and G1 isotypes. This paradoxical phenotype establishes an unanticipated inhibitory function for LAT that is critical for the differentiation and homeostasis of TH cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aguado, Enrique -- Richelme, Sylvie -- Nunez-Cruz, Selene -- Miazek, Arkadiusz -- Mura, Anne-Marie -- Richelme, Mireille -- Guo, Xiao-Jun -- Sainty, Danielle -- He, Hai-Tao -- Malissen, Bernard -- Malissen, Marie -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):2036-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre d'Immunologie de Marseille-Luminy, INSERM- and CNRS-Universite de la Mediterranee, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065839" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptor Proteins, Signal Transducing
;
Animals
;
Antigens, CD5/analysis/metabolism
;
B-Lymphocytes/immunology/physiology
;
CD4-Positive T-Lymphocytes/immunology/physiology
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CD8-Positive T-Lymphocytes/immunology/physiology
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Carrier Proteins/*genetics/*physiology
;
Cell Cycle
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Cell Differentiation
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Eosinophilia
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Eosinophils/physiology
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Histocompatibility Antigens Class II/immunology
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Immunoglobulin E/blood
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Immunoglobulin G/blood
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Interferon-gamma/genetics/metabolism
;
Interleukins/genetics/metabolism
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Leukocyte Count
;
Lymphocyte Activation
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Lymphoid Tissue/cytology/immunology
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*Membrane Proteins
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Mice
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Mice, Inbred BALB C
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Phenotype
;
Phosphoproteins/*genetics/*physiology
;
*Point Mutation
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Receptors, Antigen, T-Cell/analysis
;
Signal Transduction
;
T-Lymphocyte Subsets/immunology/physiology
;
Th2 Cells/*immunology/physiology
;
Thymus Gland/cytology/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
