Publication Date:
2002-02-23
Description:
The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, with Brn-1(-/-)/Brn-2(-/-) mice exhibiting cortical inversion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McEvilly, Robert J -- de Diaz, Marcela Ortiz -- Schonemann, Marcus D -- Hooshmand, Farideh -- Rosenfeld, Michael G -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1528-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0648, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859196" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/cytology/embryology/metabolism
;
Cell Adhesion Molecules, Neuronal/genetics/metabolism
;
Cell Line
;
Cell Movement
;
Cerebral Cortex/cytology/embryology/*metabolism
;
Cyclin-Dependent Kinase 5
;
Cyclin-Dependent Kinases/metabolism
;
Extracellular Matrix Proteins/genetics/metabolism
;
Female
;
Gene Targeting
;
Hippocampus/cytology/embryology/metabolism
;
Homeodomain Proteins
;
In Situ Hybridization
;
Male
;
Mice
;
Mutation
;
Nerve Tissue Proteins/genetics/metabolism
;
Neurons/*physiology
;
Neuropeptides/genetics/*physiology
;
POU Domain Factors
;
Serine Endopeptidases
;
Trans-Activators/genetics/*physiology
;
Transcription Factors/genetics/*physiology
;
*Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
