Publication Date:
2001-04-28
Description:
Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robo receptors are required for both functions. Mesoderm cells expressing Robo receptors initially migrate away from Slit at the midline. A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kramer, S G -- Kidd, T -- Simpson, J H -- Goodman, C S -- NS18366/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 27;292(5517):737-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11326102" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Body Patterning
;
Cell Fusion
;
Cell Movement
;
Drosophila/embryology/genetics
;
*Drosophila Proteins
;
Embryo, Nonmammalian/cytology/metabolism
;
Epidermis/embryology/metabolism
;
Mesoderm/*cytology/metabolism
;
Microscopy, Confocal
;
Muscles/*cytology/embryology/metabolism
;
Mutation
;
Nerve Tissue Proteins/genetics/*metabolism
;
Receptors, Immunologic/genetics/*metabolism
;
Signal Transduction
;
Stem Cells/metabolism/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
