Publication Date:
2011-05-20
Description:
Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091722/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091722/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Laflamme, Michael A -- Murry, Charles E -- P01 HL094374/HL/NHLBI NIH HHS/ -- R01 HL084642/HL/NHLBI NIH HHS/ -- UL1 RR025014/RR/NCRR NIH HHS/ -- England -- Nature. 2011 May 19;473(7347):326-35. doi: 10.1038/nature10147.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21593865" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cellular Reprogramming
;
Heart/growth & development/physiology
;
Heart Failure/genetics/*pathology/surgery/*therapy
;
Humans
;
Myocytes, Cardiac/cytology/pathology
;
Regeneration/genetics/*physiology
;
*Regenerative Medicine/methods
;
Stem Cell Transplantation
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
