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Preeclampsia: Animal models for a human cure [Commentary] (2011)

Aubuchon, M., Schulz, L. C., Schust, D. J.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2011-01-26

Description: Preeclampsia (PE) affects ∼5% of human pregnancies and is a leading cause of perinatal mortality, preterm birth, and maternal morbidity (1). Through positive effects on vascular tone and glomerular capillary health, vascular endothelial growth factor (VEGF) and placental growth factor (PGF) are necessary for normal pregnancy (2–4). In PE, these proteins are antagonized by excessive placental production of soluble fms-like tyrosine kinase-1 (sFLT1), a splice variant of the VEGF receptor (2, 3), and in later pregnancy, by soluble endoglin (sENG), a soluble form of a transforming growth factor beta (TGFB1) receptor that prevents binding of TGFB1 to membrane-bound endoglin (5)....

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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