Publication Date:
2018-09-28
Description:
Nuclear lamina dysfunction triggers a germline stem cell checkpoint Nuclear lamina dysfunction triggers a germline stem cell checkpoint, Published online: 27 September 2018; doi:10.1038/s41467-018-06277-z Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation.
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
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Natural Sciences in General
,
Physics