Publication Date:
2017-12-22
Description:
The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis, Published online: 21 December 2017; doi:10.1038/s41467-017-02339-w New Delhi metallo-β-lactamases (NDMs) hydrolyze almost all β-lactam antibiotics and pose a major public health threat. Here, the authors study the mechanism of NDM-1 catalyzed carbapenem hydrolysis and present the crystal structures of the enzyme-intermediate and product complexes, which is important for drug design.
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
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Natural Sciences in General
,
Physics