Publication Date:
2017-01-28
Description:
mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis Nature Communications, Published online: 27 January 2017; doi:10.1038/ncomms14208 mTORC1 and mTORC2 are alternatively required for differentiation of T cells into Th1/Th17 or Th2 cells. Here the authors show mTORC2 signalling is also needed for IL-4-induced M2 activation with functional evidence provided by a N. brasiliensis infection model and cold challenge to model adaptive thermogenesis.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics