Publication Date:
2016-07-24
Description:
Article The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessary for scar formation after injury, and can revert back to a less-activated state upon injury resolution. Nature Communications doi: 10.1038/ncomms12260 Authors: Onur Kanisicak, Hadi Khalil, Malina J. Ivey, Jason Karch, Bryan D. Maliken, Robert N. Correll, Matthew J. Brody, Suh-Chin J. Lin, Bruce J. Aronow, Michelle D. Tallquist, Jeffery D. Molkentin
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics