Publication Date:
2016-03-05
Description:
Article Regenerative tissue engineering with mesenchymal stem cells is hampered by bulk methods of assessing differentiation status and a general assumption that expression of individual markers of stem cell differentiation correlate with functional capacity. Here the authors debunk this assumption by applying single-cell techniques to disassociate aggrecan mRNA abundance and matrix deposition. Nature Communications doi: 10.1038/ncomms10865 Authors: Allison J. Cote, Claire M. McLeod, Megan J. Farrell, Patrick D. McClanahan, Margaret C. Dunagin, Arjun Raj, Robert L. Mauck
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics