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Functional Analyses of Transcription Factor Binding Sites that Differ between Present-Day and Archaic Humans (2016)

Weyer, S., Pääbo, S.

Oxford University Press

In: Molecular Biology and Evolution

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Publication Date: 2016-01-24

Description: We analyze 25 previously identified transcription factor binding sites that carry DNA sequence changes that are present in all or nearly all present-day humans, yet occur in the ancestral state in Neandertals and Denisovans, the closest evolutionary relatives of humans. When the ancestral and derived forms of the transcription factor binding sites are tested using reporter constructs in 3 neuronal cell lines, the activity of 12 of the derived versions of transcription factor binding sites differ from the respective ancestral variants. This suggests that the majority of this class of evolutionary differences between modern humans and Neandertals may affect gene expression in at least some tissue or cell type.

Print ISSN: 0737-4038

Electronic ISSN: 1537-1719

Topics: Biology

Published by Oxford University Press

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