Publication Date:
2015-10-14
Description:
Article FR171456 is a bioactive chemical produced by some microorganisms. Here, the authors identify the enzyme NSDHL of the sterol synthesis pathway as the molecular target of FR171456, rendering it the first compound to specifically target this class of enzyme in yeast and mammalian cells. Nature Communications doi: 10.1038/ncomms9613 Authors: Stephen B. Helliwell, Shantanu Karkare, Marc Bergdoll, Alain Rahier, Juliet R. Leighton-Davis, Celine Fioretto, Thomas Aust, Ireos Filipuzzi, Mathias Frederiksen, John Gounarides, Dominic Hoepfner, Andreas Hofmann, Pierre-Eloi Imbert, Rolf Jeker, Richard Knochenmuss, Philipp Krastel, Anais Margerit, Klaus Memmert, Charlotte V. Miault, N. Rao Movva, Alban Muller, Hans-Ulrich Naegeli, Lukas Oberer, Vivian Prindle, Ralph Riedl, Sven Schuierer, Jessica A. Sexton, Jianshi Tao, Trixie Wagner, Hong Yin, Juan Zhang, Silvio Roggo, Stefan Reinker, Christian N. Parker
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics