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    The Rise and Fall of Hyaluronan in Respiratory Diseases (2015)
    Hindawi
    Details
    Publication Date: 2015-09-11
    Description: In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following pulmonary injury, elevated levels of HA matrices accumulate in these regions, and in respiratory secretions, correlating with the extent of injury. Animal models have provided important insight into the role of HA in the onset of pulmonary injury and repair, generally indicating that the induction of HA synthesis is an early event typically preceding fibrosis. The HA that accumulates in inflamed airways is of a high molecular weight (〉1600 kDa) but can be broken down into smaller fragments (
    Print ISSN: 1687-8876
    Electronic ISSN: 1687-8884
    Topics: Biology
    Published by Hindawi
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