Publication Date:
2015-02-03
Description:
A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%, and an overall atom economy of 82.7%.Graphical AbstractStarting from 3-nitropropanyl chloride, Fingolimod was obtained in 4 steps with an overall yield of 31%.
Electronic ISSN:
1752-153X
Topics:
Chemistry and Pharmacology