Publication Date:
2014-08-23
Description:
Article Polyglutamine repeat expansion in ataxin-3 causes neurodegeneration in spinocerebellar ataxia type 3, and reducing the levels of the mutant protein improves pathology. Here the authors show that ataxin-3 is degraded through an ubiquitination-independent mechanism that is impeded by protein interactions with proteasome-associated factors. Nature Communications doi: 10.1038/ncomms5638 Authors: Jessica R. Blount, Wei-Ling Tsou, Gorica Ristic, Aaron A. Burr, Michelle Ouyang, Holland Galante, K. Matthew Scaglione, Sokol V. Todi
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics