Publication Date:
2013-06-21
Description:
Article LIS1 has been shown to act as a protein ‘clutch’, which binds to dynein motor proteins and prevents microtubule detachment without affecting their ATPase activity; this causes dynein to stall. Here the authors show that the GTPase Rab6a releases LIS1 from dynein, thus reactivating the motor. Nature Communications doi: 10.1038/ncomms3033 Authors: Masami Yamada, Kanako Kumamoto, Shintaro Mikuni, Yoshiyuki Arai, Masataka Kinjo, Takeharu Nagai, Yoshikazu Tsukasaki, Tomonobu M Watanabe, Mitsuru Fukui, Mingyue Jin, Shiori Toba, Shinji Hirotsune
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics