Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉Factors that mediate sterol-regulated targeting of SREBP/SCAP to COPII vesicles for lipid homeostasis are unknown. Cideb is an ER/lipid droplet-localized protein that binds escort factor SCAP and SAR21 GTPase to promote ER-to-Golgi transport of SREBBP/SCAP on COPII vesicles.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉Cideb deficiency abrogates COPII-mediated SREBP activation in mouse liver.〈/p〉〈/li〉
〈li〉〈p〉Sterol-controlled Cideb/SCAP interaction regulates SREBP processing and sterol sensitivity.〈/p〉〈/li〉
〈li〉〈p〉Cideb transfers SCAP/SREBP to the active budding machinery by interacting with Sec12.〈/p〉〈/li〉
〈li〉〈p〉Loss of Cideb inhibits the cargo loading of SREBP/SCAP, reduces SREBP activation, and protects mice from diet-induced non-alcoholic fatty liver disease.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine