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Salivary Pharmacodynamics and Bioavailability of Promethazine in Human Subjects (1999)

Putcha, Lakshmi ; Berens, Kurt L. ; Harm, Deborah L. ; [et al.]

In: CASI

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Publication Date: 2004-12-03

Description: The acute effects of exposure to microgravity include the development of space motion sickness which usually requires therapeutic intervention. The current drug of choice, promethazine (PMZ), has side effects which include nausea, drowsiness, dizziness, sedation and impaired psychomotor performance. In a ground-based study with commercial airline pilots and shuttle simulator trainers, we measured sleep and psychomotor performance variables, and physiological variables such as blood pressure and heart rate, as a function of circulating drug concentrations in the body. We evaluated a non-invasive sampling method (saliva) as a means of assessing pharmacodynamics following a single intramuscular (IM) dose of PMZ.

Keywords: Aerospace Medicine

Type: Proceedings of the First Biennial Space Biomedical Investigators' Workshop; 462-463

Format: text

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