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Histamine H2 receptor - Involvement in gastric ulceration (1976)

Vernikos-Danellis, J. ; Brown, T. H. ; Brown, P. A.

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Publication Date: 2011-08-16

Description: The involvement of the H1 and H2 receptors for histamine in the pathogenesis of gastric ulcers was investigated in rats. Metiamide, an H2 receptor antagonist, reliably reduced ulceration produced by stress alone or by a combination of stress and aspirin. In contrast, pyrilamine, which blocks only the H1 receptor, was without effect under these same conditions. The results support the hypothesis that histamine mediates both stress and stress plus aspirin induced ulceration by a mechanism involving the H2 receptor.

Keywords: LIFE SCIENCES (GENERAL)

Type: Life Sciences; 18; 1976

Format: text

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