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Alteration of pituitary-adrenal dynamics induced by a water deprivation regimen (1974)

Vernikos-Danellis, J. ; Sakellaris, P. C.

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Publication Date: 2011-08-16

Description: Experiments are described which were designed to assess the degree of adaptation that occurs in rats chronically exposed to the stress of a water-deprivation regimen and to determine if that adaptation represents a normalization of the hypothalamic-pituitary-adrenal axis. There were no significant differences in mean corticosterone concentrations among control nondeprived rats 1, 4, and 8 weeks after the start of the experiment. The water-deprived rats, however, had significantly elevated plasma steroids 1 and 4 weeks after the onset of deprivation as compared to controls, but not after 8 weeks. Thus, there was a significant decrease in mean plasma corticosterone levels during water deprivation from 1 week to 8 weeks.

Keywords: BIOSCIENCES

Type: Physiology and Behavior; 12; 1974

Format: text

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