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Cell Death Mechanisms in the Human Opportunistic Pathogen Candida albicans (2003)

Lemar, Katey M. ; Müller, Carsten T. ; Plummer, Susan ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

The @journal of eukaryotic microbiology 50 (2003), S. 0

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ISSN: 1550-7408

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: . Difficulties arising during chemotherapy of Candida albicans necessitate novel chemotherapeutic strategies. Garlic extract and two of its constituents, diallyl disulphide and allyl alcohol, are potentially useful anti-candidal agents. Flow Cytometry has been used to measure the population distributions of apoptotic/necrotic cell death using annexin V-FITC/propidium iodide and oxidative stress dichlorodihydrofluorescein. Candicidal mechanisms may be due to programmed cell death induced by oxidative stress, mediated by the generation of reactive oxygen species or alternatively by the depletion of cellular thiols, which normally act as redox buffer systems for defence. We suggest that mechanisms that these anti-candidal agents have in common is the triggering some of the characteristics of apoptotic cell death.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1550-7408.2003.tb00687.x

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