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Evaluation of a standardized F1 capsular antigen capture ELISA test kit for the rapid diagnosis of plague (2004)

Splettstoesser, Wolf D. ; Rahalison, Lila ; Grunow, Roland ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

FEMS immunology and medical microbiology 41 (2004), S. 0

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ISSN: 1574-695X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology , Medicine

Notes: Rapid detection of soluble F1 capsular antigen in serum, bubo fluid or urine of patients proved to be a valuable tool in the presumptive diagnosis of plague.We evaluated a F1 capsular antigen capture ELISA resembling a commercially available test kit. The minimal detectable concentration was 4 ng/ml. The specificity was 100% when investigating 47 sera from healthy Malagasy subjects and 98.4% when 365 sera from German blood donors were studied. Sensitivity was determined on sera (n=11) and buboes (n=18) from bacteriologically confirmed Malagasy plague patients. Sensitivity was 90.1% for serum and 100% for buboes.A standardized F1 capsular antigen capture ELISA test kit might be well suited for the early detection of plague particularly in non-endemic areas where clinical microbiological laboratories have only limited access to alternative techniques for rapid identification of Yersinia pestis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/j.femsim.2004.02.005

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