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Mycoplasmas regulate HIV-LTR-dependent gene expression (1995)

Nir-paz, Ran ; Israel, Shoshana ; Honigman, Alik ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 128 (1995), S. 0

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ISSN: 1574-6968

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: Abstract Mycoplasmas have been incriminated in setting the stage for HIV infection and full-blown AIDS. We tested the possible involvement of mycoplasmas in activation of HIV. Two cell lines, 293 fibroblasts and Jurkat CD4+ T-cells, transfected with plasmids harboring a transcription fusion construct between HIV-long terminal repeat (HIV-LTR) and either luc or cat genes, were infected with several mycoplasmas (M. fermentons; M. penetrons M. pirum and Ureaplasma urealyticum) and the reporter gene expression was monitored. The data presented here suggest that mycoplasmas, and specifically their membranes, play a role in the activation of HIV-LTR mediated transcription.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1574-6968.1995.tb07501.x

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