ISSN:
1574-6968
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
Abstract We prepared mutants of Streptomyces cinnamonensis resistant to amino acid analogues: 2-aminobutyrate, norvaline, norleucine, 2-amino-3-chlorobutyrate and ethionine. The regulatory mutants were studied as to their production of oligoketide antibiotics, monensins A and B, as dependent on the formation of valine which is a precursor of the butyrate building unit of monensin A. Strains resistant to both 2-amino-3-chlorobutyrate and norleucine exhibited an increased production of monensin A from 50% to 90–93% of total monensins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1574-6968.1984.tb01306.x