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Interaction between lactoferrin and ovotransferrin and Candida cells (1986)

Valenti, Piera ; Visca, Paolo ; Antonini, Giovanni ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 33 (1986), S. 0

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ISSN: 1574-6968

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: Abstract The mechanism of antifungal activity of lactoferrin (Lf) and ovotransferrin (OTR) towards Candida albicans and Candida krusei was studied. In low iron-content medium, in minimal medium supplemented by 2,2′-dipyridyl, and in a medium in which Lf or OTR were separated from the culture by a dialysis membrane, the growth of C. albicans and C. krusei was proportional to the endogenous iron. Differences were observed when Lf or OTR was in contact with the fungal cells: C. albicans was inhibited, whereas C. krusei was not. Direct fluorescence indicated binding of Lf and OTR only on C. albicans surfaces, and suggested that antifungal activity is not simply related to iron deprivation, but involves interaction of the protein with the fungal surface.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1574-6968.1986.tb01285.x

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