ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
To enhance the stability of liposomes in systemic circulation, a number of liposomesmodified with hydrophilic polymer such as poly(ethylene oxide) have been developed. In this study,the comb-type copolymer was prepared as a surface modifier of liposome and the polymer wasanchored onto the lipid bi-layer via hydrophobic interaction between aliphatic chain ofphospholipids and hydrophobic chain of the polymer. The comb-type copolymer was synthesizedby radical polymerization of octadecyl acrylate (ODA), hydroxy-poly-(oxyethylene) methacrylate(HPOEM) and 2-Hydroxyethyl methacrylate (HEMA). The structure of the comb-type copolymerwas confirmed by 1H-NMR analysis. The stability of the comb-type copolymer-incorporatedliposomes (CCIL) in serum was investigated by measuring the amount of protein adsorbed ontoliposomes. The CCIL showed a much lower amount of adsorbed protein than the other liposomes.Those results indicated that the stability of CCIL in serum was higher than those of the otherliposomes. Thus, the comb-type copolymer composed of ODA-HPOEM-HEMA can be a promisingsurface modifier for enhancement of the stability of liposomes in systemic circulation
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.733.pdf
