ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The purpose of this study is to explore the osteoinductivity of the composite materials (calciumphosphate ceramics/PLA or collagen composites) with similar physical character of osteoinductivecalcium phosphate ceramics and the influence of the chemical composition of the composite materials onosteoinductivity, and also to provide an experimental evidence for optimizing the design of the compositematerials. Two kinds of composite materials were prepared. One (BCP/PLA) is fabricated with differentratio of BCP (biphasic calcium phosphate) ceramics powder and PDLLA powder through the particulateleachingtechnique. The other (BCP/collagen) is that BCP ceramics sintered at 1250oC and modified withcollagen. The porous materials cylinders with Φ 5×8 mm were prepared. SEM was used to observe themicrostructure and physical morphology of the composite materials. The two groups of compositematerials cylinders were implanted in the dorsal muscles of four dogs. Six samples of each group wereimplanted in each dog respectively. The specimens were harvested at 2, 4, 12 and 24 weeks post operation,and thin decalcified sections were prepared for light microscopy (LM) analysis to evaluate theirosteoinductivity and compare the capability of osteoinduction. The fibro-tissue and bone-like tissue wereobserved in the two composites, but no obvious bone formation was found in the tested periods. Theresults indicated that the composite materials could modify the mechanical property of ceramics.However, if the composite materials were biodegraded soon, new bone could not form into the scaffold,and the calcium phosphate should be the major component of osteoinductive materials
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1638.pdf
