ISSN:
1662-9752
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
N-carboxyethyl chitosan (ACS) was formed by a Micheal reaction. Through the analysisof IR and 1H-NMR spectra, the Micheal reaction was carried out between - NH2 of chitosan and - C= C - of acrylic acid. ACS hydrogel (ACSG) was prepared by cross-linking with glutaraldehyde.ACSG show pH-sensitive swelling behavior, and the smallest swelling rate (SR) of ACSG is in pH5.0buffer solution.With dosage of glutaraldehyde increasing, the SR of ACSG decreased. With graftingdegree (GD) increasing, the SR of ACSG increased first and decreased afterward. Using bovineserum albumin (BSA) as a model medicine, the releasing behaviors of ACSG were investigated invitro. In simulated gastric and intestinal fluid, the ACSG loading BSA (GD=20.45%) has betterreleasing behaviors
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.561-565.1455.pdf
