ISSN:
1600-5368
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
A dimeric analogue of desoxazoline ascidiacyclamide was synthesized to increase the conformational flexibility of the molecule. The overall structure of this compound, C72H112N16O16S4·3C3H7NO·H2O, was relatively flat and was classified neither as the folded nor squared form, which have been observed in ascidiacyclamide analogues. Rather, a unique β-sheet was formed in the 48-membered ring with pseudo-twofold symmetry. This was stabilized by hydrogen bonds including C—H...O interactions between thiazole and carbonyl O atoms. This is the first structure of an ascidiacyclamide analogue to exhibit a flat conformation composed of a β-sheet.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S160053680101279X