ISSN:
1612-1112
Keywords:
Supercritical fluid chromatography
;
Flow switching pressure regulator
;
Pressure programming
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The newly developed regulating valve is based on high-speed flow switching, and is capable of controlling the column outlet pressure independent of the mass flow-rate of the fluid. The reproducibility of retention times in pressure-programming elution on a 4.6 mm i.d. ×250mm long silica gel column was better than 1% with supercritical carbon dioxide as the mobile phase. The outlet mass flow-rate decreased while the pressure was increasing, keeping the input flow to the system constant; this was due to the compressibility of the fluid. The amount of decrease in the outlet flow was calculated by introducing an analogous circuit model and new parameters, instrumental and column capacitances. The result agreed with the measured value within 30% error.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02262088