ISSN:
1435-1536
Keywords:
Controlled release of drug
;
capsule
;
poly(α amino acid)s
;
membrane
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Abstract The release behavior of a water-soluble drug through membranes made of poly(L-leucine) and its copolymer with different hydrophilic properties was studied. The effect of casting methods on the release rate was also investigated. It was found that the membrane with a higher hydrophilic property resulted in a higher permeation rate. The capsule was prepared as a composite sheet from a poly(L-leucine)-prednisolone 21-sodium succinate sponge and a poly(L-leucine) membrane. Release of the water-soluble drug from the capsule was found to be effectively governed by the hydrophilic character and thickness of the outer membrane. Biocompatibility studies carried out by implanting the poly(L-leucine) sponge subcutaneously in the dorsal surface of the rat showed that the sponge had a good biocompatibility and slow biodegradation. It was concluded from these results that poly(L-leucine) should be a suitable material for preparing a controlledrelease drug device for long-term dosage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01411497
