ISSN:
1435-1536
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Description / Table of Contents:
Zusammenfassung Partikel von Arzneimittelsuspensionen bleiben sehr oft an den Behälterwänden hängen und verursachen bei der Handhabung der Suspensionen viele Schwierigkeiten. Die Ursachen für dieses Verhalten werden ausführlich erläutert.
Notes:
Summary Particles of the pharmaceutical suspension often adhere on the container wall and cause several serious troubles. This adhesion proceeds by two steps; (1) particle trapping and (2) particle adhering. Particle trapping occurs only when the suspension spreads on the wall surface to make the even, thin liquid film of the medium, which traps the particles by pressure due to the surface tension of the medium acting upon the water line of the particle surface. The thinner film and the greater surface tension of the medium give the stronger trapping effect. The number of trapped particles is directly proportional to the concentration of the suspension and to square root of the particle diameter. The overall observed trappable nature of the particle was expressed by trappability constant. Some of the trapped particles develop to adhesion; the adhesion amount was proportional to the number of the particle in the unit volume of the suspension (concentration of the suspension) and related with particle diameter, wetting interval, wetting frequency, temperature, and flow rate of the suspension. pH of the medium did not give any effect on the adhesion. The important rôle of a thin liquid film for the adhesion, was also investigated and discussed in connection with three types of the wetting.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02084726
