ISSN:
1432-1432
Schlagwort(e):
Template synthesis
;
Nucleotide analogs
;
Oligomerization
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
Notizen:
Summary 3′-Amino-3′-deoxyguanosine-5′-phosphorimidazolidate (ImpGnh 2) oligomerizes more rapidly and regiospecifically than related nucleotide derivatives on a d(CpCpCpCpC) template. The greater nucleophilicity of the amino group leads to efficient oligomerization even when the structure of the double-helical complex formed by the template and the substrate is not optimal for reaction. The use of amine-containing analogues should permit us to develop models of potentially prebiotic polymerization reactions that cannot be studied easily using natural nucleotides.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02101750