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Malignant Osteopetrosis: c-src kinase is not reduced in fibroblasts (1993)

Meyerson, Gabrielle ; Dahl, Niklas ; Påhlman, Sven

Springer

Calcified tissue international 53 (1993), S. 69-70

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ISSN: 1432-0827

Keywords: Malignant osteopetrosis ; c-src ; Fibroblasts ; Protein, kinase activity

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Summary Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could be detected in c-src protein and c-src kinase activity levels between fbroblasts from healthy controls and affected individuals. Thus, impairment of c-src function as an etiological factor in human osteopetrosis appears unlikely in the individuals investigated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01352018

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