ISSN:
1476-5535
Keywords:
Neutral resins
;
Rubradirin
;
Fermentation production
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary Rubradirin is an antibiotic of complex chemical structure which is activevs. methicillin resistant staphylococci. Its development has been limited due to inadequate production yields. The incorporation of neutral resins into fermentations ofStreptomyces achromogenes v.rubradiris, UC® 8051 resulted in the enhanced production of rubradirin. Resins HP-20, HP-21, XAD-2, XAD-7 and XAD-16 were employed in flask and tank fermentations. The incorporation of these resins promoted 2- to 4-fold enhancements of the rubradirin activity produced in flask fermentations, and the incorporation of XAD-16 and HP-21 into tank fermentations promoted production titer increases 〉5 fold.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01578202
