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Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans (1980)

Bhat, S. G. ; Babu, P.

Springer

Molecular genetics and genomics 180 (1980), S. 635-638

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ISSN: 1617-4623

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Mutants in the gene flu-2 of the free-living nematode Caenorhabditis elegans are characterised by an altered autofluorescence of the intestine cells, from the light blue of wild-type to a dull green colour. The properties of flu-2 mutants have been investigated. L-kynureninase activity has been detected in wildtype C. elegans. The flu-2 mutants have markedly reduced kynureninase activity, as predicted earlier from chromatographic analysis of trptophan catabolites of wild-type and mutant worms. Associated with this enzymatic block, all flu-2 mutants have enhanced sensitivity to ethyl methane sulfonate (EMS) and γ-rays.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00268072

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