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Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans

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Summary

Mutants in the gene flu-2 of the free-living nematode Caenorhabditis elegans are characterised by an altered autofluorescence of the intestine cells, from the light blue of wild-type to a dull green colour. The properties of flu-2 mutants have been investigated. L-kynureninase activity has been detected in wildtype C. elegans. The flu-2 mutants have markedly reduced kynureninase activity, as predicted earlier from chromatographic analysis of trptophan catabolites of wild-type and mutant worms. Associated with this enzymatic block, all flu-2 mutants have enhanced sensitivity to ethyl methane sulfonate (EMS) and γ-rays.

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Authors and Affiliations

  1. Molecular Biology Unit, Tata Institute of Fundamental Research, 400 005, Bombay, India

    S. G. Bhat & P. Babu

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  1. S. G. Bhat
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  2. P. Babu
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Communicated by Ch. Auerbach

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Bhat, S.G., Babu, P. Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans . Molec. Gen. Genet. 180, 635–638 (1980). https://doi.org/10.1007/BF00268072

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  • DOI: https://doi.org/10.1007/BF00268072

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