ISSN:
1432-0770
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Computer Science
,
Physics
Notes:
Abstract Current clamp data of the squid axon indicate that there is a qualitative change in the adaptive response as the magnitude of the current step is increased. Large stimulus currents have a strong inhibitory effect on spike generation and on active responses in general. Such currents always lead to only one action-potential and to the elimination of post-spike subthreshold oscillation. In view of a direct connection between stimulus current and potassium current I K, the potassium channel of the Hodgkin-Huxley model is reinterpreted in a natural way such that the K+ conductance is directly dependent on I K in addition to a voltage dependence. The I-Kdependence seems to dominate whenever the stimulus current is greater than approximately 35 μA/cm2. For current ramps, and large current steps, such a current formulation leads to good agreement with the data.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00337055
