ISSN:
1432-119X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The ultrastructural features of the Leu-7-positive — Leu-M3-positive cell subpopulation and the Leu-7-positive — Leu-4-positive cell subpopulation were characterized and compared using immunogold-immunoperoxidase double labelling with immunoelectron microscopy. The majority of Leu-7-positive cells coexpressed a monocyte phenotype and showed an ultrastructural pattern specific for functional natural killer (NK) cells, i.e. a low nuclear/cytoplasmic (N/C) ratio, an irregular outline, many cytoplasmic organelles and electron-dense granules. In contrast, only a minority of Leu-7-positive cells coexpressed a T phenotype, and these were characterized by a high N/C ratio, an even surface and the absence of electron-dense granules. Thus, Leu-7-positive — Leu-4-positive cells may by an immature form of NK cells, and Leu-7-positive—Leu-4-positive and Leu-7-positive — Leu-M3-positive cell subpopulations may represent different stages of Leu-7-positive cell differentiation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00489973
