ISSN:
1432-1017
Keywords:
Key words Ion channels
;
Hirudo medicinalis
;
Periodic forcing
;
Kinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Physics
Notes:
Abstract An unconventional approach to studying ion channel kinetics is exploited. Here we describe the effects of a periodically varying membrane potential on the open-closed transitions of single K+ channels. The use of cycle histograms allows one to measure the transition probabilities as functions of the stimulus phase. The results show that such probabilities vary with the stimulation frequency and with the stimulus history, thus highlighting a dynamic aspect in the switching of this ion channel.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002490050137