ISSN:
1432-1041
Keywords:
Fluconazole
;
haemodialysis
;
fungal infection
;
Uraemia pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5) % (n=4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2) % (n=5) and 39 (2.2) % (n=9) respectively. The estimated amount extracted by a dialysis of 4 h was 33 (3.2) % (n=4) of the dose. During repeated administration the serum fluconazole concentration increased, reaching a plateau at about 4 times the peak concentration after the first dose. After discontinuing administration the serum fluconazole concentration fell by 25% in every 3 h dialysis session. We conclude that fluconazole should be given in the usual dose of 100 or 200 mg at the end of every haemodialysis session.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00265934
