ISSN:
1432-1041
Keywords:
pirenzepine
;
renal insufficiency
;
haemodialysis
;
steady-state pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The steady-state intravenous pharmacokinetics of pirenzepine has been investigated in 57 subjects whose renal function ranged from normal to chronic failure requiring regular haemodialysis. Pirenzepine renal clearance, total clearance and terminal (dominant) half-life were found to be correlated with the creatinine clearance (CLCR), but this was not the case for the volume of distribution and the nonrenal clearance. The therapeutic regimen was well tolerated by all subjects. Haemodialysis did not significantly contribute to the elimination of pirenzepine. Dosage adjustment need only be considered in patients with CLCR〈25 ml/min in order to reduce the frequency of minor side-effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561028
