ISSN:
1432-1041
Keywords:
caffeine
;
idrocilamide
;
xanthine derivatives
;
inhibition of metabolism
;
neuropsychiatric side effects
;
pharmacokinetics
;
healthy man
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561675